Glyphosate Causes Irreversible Abnormal Growth & Delayed Development of Embryonic Rat Neuronal Cells

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ISIS Report 20/01/16
Glyphosate Causes Irreversible Abnormal Growth & Delayed Development of Embryonic Rat Neuronal Cells Primary rat neuronal cultures exposed to glyphosate showed abnormal morphology, delayed differentiation and decreased activity of a Wnt signalling pathway involved in embryonic development Dr Eva Sirinathsinghji
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A new study finds that cultured embryonic rat neurones exposed to sub-lethal doses of glyphosate show a delay in development characterised by reduced neuronal polarisation, complexity and morphology.  Underlying the abnormalities was reduced activity of a Wnt protein Wnt5a, a signalling transduction molecule, as well as its downstream signalling effector CaMKII (Ca2+/calmodulin-dependent protein kinase II). Effects of glyphosate were rescued through the restoration of normal Wnt signalling activity, validating its involvement in glyphosate?s neurotoxic effects.

The toxicity of glyphosate herbicides and their formulation products are widely recognised in the scientific literature, with evidence accumulating on its neurotoxic effects (see [1] Banishing Glyphosate, Special ISIS report). Studies have linked glyphosate to Parkinson?s disease following acute exposure, increased seizures in epileptic patients, and deficits in learning and memory; and there is epidemiological evidence of increased behavioural problems in children such as ADHD (see [1]). Further, a recent investigation into neurotoxic mechanisms identified increased oxidative stress and cell death in the hippocampus of exposed rats linked to increased levels of extracellular glutamate neurotransmitter [2]. Nevertheless, cellular mechanisms underlying nervous system damage remained unknown.

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Venezuela Bans GMOs And Prohibits Seed Patenting

‘The country recently approved a law that will ban the production, distribution, and importation of GM seeds. To protect heirloom seeds and organic farmers, the country of Venezuela, through its National Assembly, recently approved a law that will ban the production, distribution, and importation of GM seeds.

http://www.naturalblaze.com/2015/12/venezuela-bans-gmos-and-prohibits-seed-patenting.html

GMWatch Review 362

Philippines Supreme Court ban on GMOs a “major setback” for the GM industry

The Supreme Court of the Philippines has ordered a permanent ban on field trials of GM eggplant and a temporary halt on approving applications for the “contained use, import, commercialisation and propagation” of GM crops, including the import of GM products. The court ruled in favour of Greenpeace Southeast Asia and fellow campaigners in a major victory for Filipino farmers and activists. Virginia Benosa-Llorin, Ecological Agriculture Campaigner for Greenpeace Philippines, called the ruling “a major setback for the GE industry”. It will affect GM golden rice, which is currently back at the R&D stage after proving a disappointment in field trials.

http://www.gmwatch.org/news/news-reviews/16597-review-362

Scientists challenge EFSA claim of glyphosate safety

In November, the European Food Safety Authority (EFSA) concluded that glyphosate is “unlikely to pose a carcinogenic hazard to humans”.

The EFSA decision, based on the Renewal Assessment Report provided by the German federal risk assessment institute BfR, ran counter to the finding earlier this year by the International Agency for Research on Cancer (IARC), the cancer arm of the World Health Organization, that glyphosate is a probable human carcinogen. The IARC review linked glyphosate to dose-related increases in malignant tumours at multiple anatomical sites in experimental animals and to an increased incidence of non-Hodgkin lymphoma in exposed humans.

http://www.gmwatch.org/news/latest-news/16568

Study Linking GMOs and Tumors Vindicated Yet Again

Monsanto Face People’s Trial for Crimes against Humanity

The Organic Consumers Association (OCA), IFOAM International Organics, Navdanya, Regeneration International (RI), and Millions Against Monsanto, joined by dozens of global food, farming and environmental justice groups announced today that they will take Monsanto MON (NYSE), a US-based transnational corporation, to a people’s trial for crimes against nature and humanity, and ecocide, in The Hague, Netherlands, next year on World Food Day, October 16, 2016.

http://sustainablepulse.com/2015/12/03/monsanto-put-on-trial-for-crimes-against-humanity-in-the-hague/#.Vm5d7V51u2b

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