DNA damage and methylation induced by glyphosate in peripheral blood mononuclear cells

Please cite this article as: Kwiatkowska, M., Reszka, E., Woźniak, K., Jabłońska, E., Michałowicz, J., Bukowska, B., DNA damage and methylation induced by glyphosate in peripheral blood mononuclear cells (in vitro study), Food and Chemical Toxicology (2017), doi: 10.1016/j.fct.2017.03.051.

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Glyphosate Exposure and Increased Frequency of Cancer in Argentina

Glyphosate Exposure and Increased Frequency of Cancer in Argentina

In 1996, Argentina began to grow genetically modified (GM) crops, which currently cover 25 million hectares on which 12 million people live. These crops have generated a substantial increase in pesticide use. In 2013, Argentina sprayed 240,000 tons of glyphosate.

The town of Monte Maiz lies at the heart of Argentina’s agricultural area, where soy, maize, and wheat are grown. In recent years, local governmental authorities along with local residents and doctors have been worried about an apparent increase in the number of people suffering from cancer, in particular since the introduction of GM herbicide-resistant crops and the massive use of glyphosate in conjunction. The Mayor and residents of Monte Maiz requested an environmental health study.

Read more: Glyphosate Exposure and Increased Frequency of Cancer in Argentina

'Golden Rice': Unexpected genomic effects

15 February 2017 / A new publication has reported unintended effects in genetically engineered rice producing precursors of vitamin A, so-called carotenoids. Crossing the manipulated rice with the Indian variety Swarna led to a nasty surprise: The resulting plants showed extensive disturbance in their growth. The researchers identified several reasons for this: The new gene constructs interfere with the plant’s own gene for producing growth hormones, and the additional gene constructs were not, as intended, active solely in the kernels, but also in the leaves. This led to a substantial reduction in the content of chlorophyll that is essential for vital functions in the plants.


Molecular and Functional Characterization of GR2-R1 Event Based Backcross Derived Lines of Golden Rice in the Genetic Background of a Mega Rice Variety Swarna

Homozygous Golden Rice lines developed in the background of Swarna through marker assisted backcross breeding (MABB) using transgenic GR2-R1 event as a donor for the provitamin A trait have high levels of provitamin A (up to 20 ppm) but are dwarf with pale green leaves and drastically reduced panicle size, grain number and yield as compared to the recurrent parent, Swarna. In this study, we carried out detailed morphological, biochemical and molecular characterization of these lines in a quest to identify the probable reasons for their abnormal phenotype. Nucleotide blast analysis with the primer sequences used to amplify the transgene revealed that the integration of transgene disrupted the native OsAux1 gene, which codes for an auxin transmembrane transporter protein. Real time expression analysis of the transgenes (ZmPsy and CrtI) driven by endosperm-specific promoter revealed the leaky expression of the transgene in the vegetative tissues. We propose that the disruption of OsAux1 disturbed the fine balance of plant growth regulators viz., auxins, gibberellic acid and abscisic acid, leading to the abnormalities in the growth and development of the lines homozygous for the transgene. The study demonstrates the conserved roles of OsAux1 gene in rice and Arabidopsis.


TWN Biosafety Info: Assessment of Stacked Bt Soybean Overlooks Potential Health Risks



Dear Friends and Colleagues

Assessment of Stacked Bt Soybean Overlooks Potential Health Risks

In June 2012, the European Food Safety Authority (EFSA) approved, for the first time, genetically engineered stacked soybean MON87701 × MON89788, produced by Monsanto and sold under the brand name Intacta, for import and use in food and feed in the EU. The soybeans combine the expression of an insecticidal Bt toxin, Cry1Ac, present in the parental event MON87701, with herbicide resistance to glyphosate from parental event MON89788.

Read more: TWN Biosafety Info: Assessment of Stacked Bt Soybean Overlooks Potential Health Risks

GMO Maize NOT equivalent!

An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process

Glyphosate tolerant genetically modified (GM) maize NK603 was assessed as ‘substantially equivalent’ to its isogenic counterpart by a nutrient composition analysis in order to be granted market approval. We have applied contemporary in depth molecular profiling methods of NK603 maize kernels (sprayed or unsprayed with Roundup) and the isogenic corn to reassess its substantial equivalence status. Proteome profiles of the maize kernels revealed alterations in the levels of enzymes of glycolysis and TCA cycle pathways, which were reflective of an imbalance in energy metabolism.



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